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KMID : 1161420230260070521
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Journal of Medicinal Food
2023 Volume.26 No. 7 p.521 ~ p.527
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Effect of Fucoxanthin on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
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Armando Lopez-Ramos
Manuel Gonzalez-Ortiz
Esperanza Martinez-Abundis
Karina G. Perez-Rubio
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Abstract
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The aim of this study was to evaluate the effect of fucoxanthin on metabolic syndrome (MetS), insulin sensitivity, and insulin secretion. A randomized, double-blind, placebo-controlled clinical trial was conducted in 28 patients diagnosed with MetS. Patients were randomly assigned to receive 12?mg of fucoxanthin or placebo once a day for 12 weeks. Before and after the intervention, the components of MetS, insulin sensitivity (Matsuda index), first phase of insulin secretion (Stumvoll index), and total insulin secretion were evaluated during a 2-h oral glucose tolerance test. After fucoxanthin administration, significant differences were observed in body weight (BW) (80.6?±?11.2 vs. 79.16?±?12.3?kg, P?
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KEYWORD
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carotenoid, fucoxanthin, insulin secretion, insulin sensitivity, metabolic syndrome
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